POSTERISAN® FORTE

Universal drug for the hemorrhoid symptoms treatment. Contains hydrocortisone to treat severe inflammation and itching.

 

Description

 

White to beige torpedo-shaped suppositories with characteristic phenol odor.

 

Indications

 

— Persistent hemorrhoids
— Anal itching, especially resistant to other medicines
— Anopapillitis
— Anal fissure

 

Dosage Regimen

 

Adults
The recommended daily dose is 2 suppositories.
Treatment should be continued until the symptoms disappear. The medicinal product should not be used continuously for more than 10 days.

Children
Posterisan Forte is contraindicated in children under 18 years of age.

 

Method of Administration

 

The suppositories should be inserted into the rectum twice daily (morning and evening), preferably after defecation.

 

Counterindications

 

— Hypersensitivity to the active ingredients or to any of the excipients
— Children under the age of 18
— Use in bacterial, fungal, or viral diseases in the treatment area
— Specific skin diseases (syphilitic or tuberculous lesions, gonorrhea)
— Vaccination reactions

 

Adverse Reactions

 

Summary of Adverse Reactions

System Organ Class	Common (≥ 1/100 to < 1/10)	Uncommon (≥ 1/1,000 to < 1/100)
General disorders and administration site conditions	Local hypersensitivity reactions (e.g., itching and burning)	Allergic contact dermatitis (due to hypersensitivity to the preservative phenol)

Prolonged use of high doses may cause skin atrophy, telangiectasia, striae, and steroid acne.

 

 

Pharmacological Properties

 

Pharmacodynamic Properties
Pharmacotherapeutic group: angioprotectives; agents for the treatment of hemorrhoids and anal fissures for topical use; other agents for the treatment of hemorrhoids and anal fissures for topical use.
Код АТХ: C05AX03

 

Mechanism of Action and Pharmacodynamic Effects
When applied topically to the skin of the anal area and the rectal mucosa, cell wall antigens and metabolic products of a standardized E. coli (Escherichia coli) bacterial culture induce a local immune response. Components of E. coli interact with antigen-presenting Langerhans cells, inducing the release of anti-inflammatory cytokines. This, in turn, reduces the production of histamine and leukotrienes, resulting in anti-inflammatory and antipruritic effects. Vascular exudation is also reduced, while blood vessel permeability and tone are normalized.
In addition, activation of antigen-presenting cells stimulates the regeneration of damaged tissues. Accelerated healing of the rectal mucosa helps reduce bleeding and pain.
Repeated administration of the standardized E. coli culture induces the proliferation of B and T lymphocytes in the regional lymph nodes and stimulates antibody production, thereby enhancing protection against infectious complications of hemorrhoidal disease.
Hydrocortisone acetate is a steroid hormone of the adrenal cortex. When applied topically, it has anti-inflammatory, desensitizing, antiallergic, vasoconstrictive, and antipruritic effects. It inhibits the release of inflammatory mediators.
When applied to the affected area, it reduces swelling, redness, and itching.

 

Preclinical Safety Data
Preclinical data obtained from conventional studies of safety pharmacology, repeated-dose toxicity, genotoxicity, carcinogenic potential, and reproductive and developmental toxicity revealed no particular hazard for humans. No irritant or toxic effects were identified with prolonged topical administration.